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Part 2 of the ESSENCE trial is expected to read out in 2029.
This pilot study is asking whether new generation GLP-1 based highly effective anti-obesity medications (HEAOMs, semaglutide and tirzepatide) cause early changes in bone health during the first year of treatment, when weight loss tends to be most rapid
It is well established for improving cholesterol and bowel regularity
Future updates to guidelines may include more details on when to use semaglutide for patients with mixed metabolic issues , such as obesity and high cholesterol without diabetes
Some users prefer starting small, testing a few low-stakes rounds, and reviewing detailed histories
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