glp-1 drugs key developments 2025 Pipeline Update: November - Prime Therapeutics GLP-1 Weight Loss Drugs: How

Our finding of suppressed BCAT2 expression, linked to AMPK/SREBP1 signaling, suggests that AMPK may influence ferroptosis regulation in TNBC

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Van Campenhout et al

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Origin and consequences of necroinflammation

Long-term risks include: gallstones chronic gallbladder inflammation need for gallbladder removal (cholecystectomy) recurrent biliary pain Thyroid Tumor Risk (Black Box Warning) Several GLP-1 drugs carry an FDA boxed warning for thyroid C-cell tumors and Medullary Thyroid Carcinoma (MTC), based on long-term rodent studies