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Losing muscle reduces basal metabolic rate , the total number of calories you need for your basic essential functions, making weight maintenance more difficult
Richard Lipman, M.D., Board Certified Internal Medicine-Endocrinology reviewed on March 16, 2026 GLP1 drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) are most famous for their gamechanging weightloss effects and effects on blood glucose control in diabetics
Researchers also plan to expand the analysis beyond Reddit and beyond English-speaking communities to determine whether similar patterns appear across other social media platforms and populations worldwide
GIP, once believed to be metabolically redundant in individuals with T2D, has been demonstrated to augment insulin secretion, improve insulin sensitivity in adipocytes, and modulate reward and satiety pathways within the CNS [64]
Jul 24, 2026 Perimenopause Weight Gain: The GLP-1, Muscle & Blood Sugar Truth Why does perimenopause weight gain happen even when you're eating right and working out