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Glycemic Efficacy: Semaglutide showed unprecedented efficacy in trials

These hormonal changes can affect hair follicles through pathways entirely separate from nutritional deficiency, which is why some patients experience hair loss despite maintaining excellent nutritional status

The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication