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These issues require careful management, which includes specific dietary guidance, appropriate medication as well as judicious dose adjustments

The number of acute pancreatitis adverse events steadily increased from 16 in 2005 to 459 in 2023 (Q1-Q3), peaking in 2011, reflecting the growing clinical utilization of GLP-1 RAs (Figure 1)

SAM, a key methyl donor, is derived from folate/one-carbon metabolism and the methionine cycle, with its levels regulated by mitochondrial metabolism, thereby controlling the supply of methylated substrates [250]

CJC-1131, a new chemical-modified GLP-1 agonist, was effective in resisting DPP-4 degradation

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10.26355/eurrev_202012_24046 Eur Rev Med Pharmacol Sci