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Giugliano D, Maiorino MI, Bellastella G, Chiodini P, Esposito G

doi: 10.1056/NEJMoa2306963 65 KosiborodMNAbildstrmSZBorlaugBAButlerJChristensenLDaviesMet al

MT-II is a cyclic heptapeptide broadly activating MC1R, MC3R, and MC4R , simultaneously producing melanogenesis alongside central pro-sexual, pro-erectile, and anorectic effects through hypothalamic MC3R/MC4R activation, Cyclisation of the -MSH pharmacophore core is the primary structural determinant of this receptor subtype selectivity shift

A typical compounded concentration for microdosing might be 1 mg/mL, allowing 0.05 mL draws for 0.05 mg doses

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