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Archived from the original on 27 November 2019

We observed that KRAS mutant cancer cell lines (HCT116 and H460) and MDA-MB-435, with a high GSTO1 expression, were sensitive to GSTO1 knockdown, but not MCF7 cells (Supplementary Fig

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In addition, EA was found to have poor low oral bioavailability, thus limiting its clinical applications

Pharmacologic inhibition of VDAC oligomerization with VBIT-4 reduced mtDNA release and attenuated interferon linked pathology in a lupus model, providing proof of principle that restricting mitochondrial danger signals escape can indirectly dampen downstream organelle coupled inflammatory signaling, including cGAS-dependent STING signaling (168)

the most common reported effects are mild, transient local reactions such as redness, itching, stinging, or dryness