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These findings suggest that higher doses of L-carnitine supplementation may not be necessary for producing the therapeutic benefits as the homeostatic control of serum L-carnitine levels is tight and subtle (15)
Effects of L-Carnitine on Mineral Metabolism in the Multicentre, Randomized, Double Blind, Placebo-Controlled CARNIDIAL Trial
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Additionally, a comparison group received synthetic Exe4 peptide via a subcutaneously implanted osmotic pump (Peptide), releasing Exe4 peptide into the host circulatory system and then removed at 8 weeks after initial implantation to simulate treatment interruption
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That is a clinically reasonable outcome, and it carries a better side effect profile for patients who are sensitive to higher doses
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