However, these adverse effects have been described as mild, with PubMed researchers concluding that berberine is a safe medicinal plant. Furthermore, no serious side effects were reported from berberine use in a study involving 2,569 patients (33)

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Glutathione is found in almost all living cells with the highest concentrations found in the liver, spleen, kidneys, pancreas and the eye
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Identification of Mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain
Understanding these results provides realistic expectations for your own protocol