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Considering the body weight reduction of more than 10% and the significant improvement in glycemic parameters without an increased risk of hypoglycemia, this trial establishes the efficacy and safety of the 7.2 mg dose of semaglutide compared with placebo in adults with obesity and type 2 diabetes, Lingvay and colleagues wrote.

While direct head-to-head trials have not been conducted, cross-trial comparisons provide useful context

Despite men typically being larger, the dose isnt adjusted for body size

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Separately, 84% of survey respondents in Novo Nordisks OPTIC patient preference study said they preferred the oral semaglutide profile over orforglipronsthough that study, too, was Novo Nordisk-funded