Lower HbA1c is associated with a reduced risk of diabetic complications such as retinopathy, neuropathy, and cardiovascular diseases
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While most approved AOMs achieve a modest weight reduction of 3% to 9% compared to placebo, randomized withdrawal studies have revealed that discontinuing AOMs often leads to regaining weight
Furthermore, challenges such as low drug concentration at the local pathological site after systemic administration, limited target specificity and short drug half-life persist [6]
Instead, they suggest considering a whole-person approach that could be more effective and cost-efficient