This increases ones risk of diabetes, heart disease, stroke, and neurodegenerative disease like Alzheimers disease
Without adequate protein intake and resistance training, a significant share of the weight lost on a GLP-1 will be lean mass rather than fat particularly concerning for older adults where sarcopenia is already a risk
GHSR agonists (Ipamorelin): These activate ghrelin/GHS receptors, stimulate GH release through a separate pathway, and may also reduce somatostatin inhibition
While GLP-1 is 300-fold more potent at stimulating beta-cell GLP-1R-induced GSIS than glucagon ( Alpha-cell GLP-1 production Evidence of intra-islet GLP-1 production In recent years, data from multiple groups have documented the existence of islet GLP-1 production
Shao M, Gao Y, Xu X, Chan DW, Du J
Many factors influence semaglutide effectiveness, including your diet, exercise, stress, sleep, and metabolic health