For instance, Tirzepatide is a dual GIP and GLP-1 receptor agonist, providing a unique approach compared to traditional GLP-1 agonists
It promotes angiogenesis (the formation of new blood vessels), boosts collagen production, and reduces inflammation
therefore, it is important to plan this appropriately and substitute another anti-hyperglycaemic agent, such as metformin or insulin, if required
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The IC50 value of truncated Ex4 is 0.6 nM compared to 1.0 nM for Ex4 and 1.6 nM for GLP-1 (Runge et al., 2008)
Still, it is a pharmacodynamically expected consequence of glucagon agonism and represents a meaningful differentiator from tirzepatide