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Essential Supplements for Bone Protection A targeted supplement regimen can make a significant difference in maintaining bone density: Calcium + Vitamin D3 Daily requirement : 1,000-1,200mg calcium and 2,000-5,000 IU vitamin D3 Best forms : Calcium citrate (more easily absorbed than calcium carbonate), vitamin D3 (cholecalciferol) Timing : Split calcium doses throughout the day for better absorption Vitamin K2 Daily requirement : 100- 200 mcg Function : Directs calcium to your bones rather than soft tissues and blood vessels Forms : MK-7 form has better bioavailability than MK-4 Magnesium Daily requirement : 320-420mg daily Forms : Magnesium glycinate or malate for better absorption and less digestive discomfort Benefits : Works synergistically with calcium and vitamin D Collagen Peptides Daily requirement : 10-15g Function : Provides the protein matrix upon which bone mineralization occurs Bonus : Also supports skin, hair, and joint health 2

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References Oral semaglutide at a dose of 25 mg in adults with overweight or obesity (2025)

GSE79397

[12] Song D, et al

In addition, GLP-1s can impact substance or alcohol use disorder and Prader-Willi syndrome through their effect on satiety hormones