Advantage: Convenient, familiar, non-invasive Challenge: Peptides face proteolytic degradation in the stomach and small intestine Bioavailability: Estimated at approximately 38% based on comparative pharmacology (see below) Transdermal (Patch) Some researchers have explored transdermal patches to deliver peptides: Advantage: Avoids first-pass metabolism and GI degradation Challenge: Intact skin is a strong barrier to peptide penetration Feasibility: Not commonly available commercially
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Furthermore, the 0.9% benzyl alcohol preservative inhibits microbial growth, allowing multi-dose use of reconstituted peptide solutions without compromising sterility
The safety and effectiveness of BPC-157 have not been thoroughly evaluated in humans
The peptide dissolves readily in bacteriostatic water without needing the osmolality adjustment that saline provides
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