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After 12 weeks, the appetite-suppressing effect typically diminishes
Nishiyama, R.J
Since their initial approval in the early 2000 s, the pharmacotherapy of GLP-1 RAs has been well recognized not only for achieving glycemic targets but also for their effectiveness in promoting satiety and weight loss, as well as their association with reductions in cardiovascular risk and all-cause mortality
The newly approved oral Wegovy at 25mg daily represents the current state of the art in FDA-approved oral GLP-1 therapy
Small things like that usually make the whole injection experience smoother after the first few weeks
Steady state takes four to five half-lives roughly four to six weeks at a constant dose
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