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Changes in sweating patterns during weight loss are commonly reported, though the reasons behind them are multifactorial

In the new substudy, once weekly semaglutide (1 mg) was shown to reduce the risk of time to first composite HF event (new onset or worsening HF leading to unscheduled hospital admission or urgent visit, with initiation of or intensified diuretic/vasoactive therapy) or cardiovascular death and HF events and cardiovascular death alone

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The Phase 2 trial specifically tested starting at 4mg versus 2mg and found that higher starting doses produced significantly more GI side effects without faster weight loss