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[Accessed 16th April 2026].
In most cases, this reflects a normal adjustment phase rather than a cause for concern, with symptoms improving as treatment continues
If the CA-125 level is 35 IU/mL or higher, an urgent ultrasound scan will be arranged, and you may be referred via the two-week wait pathway if ovarian cancer is suspected
doi: 10.1016/j.mce.2010.05.019 53
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Common adverse effects include gastrointestinal symptoms, which affect the majority of patients to varying degrees: Nausea (20-44% of patients) usually most pronounced during dose escalation Diarrhea (20-30%) Constipation (15-24%) Vomiting (9-24%) Abdominal pain (6-10%) These symptoms typically diminish over time as physiological adaptation occurs
