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A single Ipamorelin injection triggers a GH pulse lasting 24 hours, peaking 2030 minutes post-administration, then returning to baseline as the peptide clearsthis mimics the endogenous pulsatile GH secretion pattern that occurs naturally during sleep and post-exercise

The practical consequence is clear regardless of the mechanistic explanation: robust GH secretion without the hormonal background noise that complicates interpretation

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doi:10.1186/gb-2002-3-5-research0025