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A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe

Ann Intern Med (2000) 132:2708

Over time, chronic energy deficiency can lead to fatigue, poor recovery, loss of muscle, hormonal disturbances, low energy availability and impaired performance a condition akin to RED-S (Relative Energy Deficiency in Sport)

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All we're proposing to clinicians is Hey, think about the patients who are at risk and have a strategy to monitor and mitigate that risk. What about patients on GLP-1s

However, the absence of strong evidence does not mean universal suitability