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While RCTs remain the gold standard for intervention assessment, observational studies provide complementary evidence, especially when using objective biomarkers such as serum Vitamin B12, MMA, and homocysteine
The B12 solution is drawn into a sterile syringe
That same year the National Institutes of Health indicated that 1.5 percent to 15 percent of the nation is deficient
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If symptoms do not improve despite adequate B12 replacement, further investigation for other causes of nerve pain will be necessary
