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This enzymatic activity influences drug efficacy, bioavailability, and the potential for adverse drug reactions

Kreuzer PM, Landgrebe M, Vielsmeier V, Kleinjung T, De Ridder D, Langguth B

Naiki T, Naiki-Ito A, Asamoto M, Kawai N, Tozawa K, Etani T, Sato S, Suzuki S, Shirai T, Kohri K, Takahashi S

The reported values for different rows in this table were obtained under different conditions and should not be treated as a single ranking

However, whether oral bioavailability translates meaningfully to humans has not been established in clinical trials

Annu Rev Biochem 52:711760 Mezzetti F, De Vero L, Giudici P (2014) Evolved wine strains with enhanced glutathione production obtained by an evolution-based strategy