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Because, in a long-term state of hyperglycemia, the non-enzymatic glycosylation of proteins, phospholipids and nucleic acids will lead to the continuous formation and accumulation of AGE

Sotagliflozin: first global approval

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Strategy 4: Rx-to-OTC Conversion The Rx-to-OTC switch strategy seeks to convert a prescription drug to over-the-counter (OTC) status, transforming the competitive landscape from one governed by generic substitution rules to one governed by consumer brand loyalty and retail shelf positioning

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Both may have irregularities, bumps, and nodules