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doi: 10.1210/clinem/dgac166 173 SonigoCBouillyJCarrNTolleVCaratyATelloJet al
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The HMGB1/5HT7R/Nrf2/xCT/GPX4 pathway was found to promote ferroptosis of M2 microglia in transient middle cerebral artery occlusion (tMCAO) mice, which promoted ischemic brain injury and depressive-like behaviors
Direct interactions are related primarily to gut radiation and microbiota homeostasis, while indirect interactions are more related to other axes, like the MGBA
OReilly et al, 2023)
None of these mechanisms directly target appetite, fat metabolism, or caloric regulation
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