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Moreover, given that dopamine agonist treatment in PD is limited by their intolerable side effects and diminished effectiveness over time, we selected astrocyte-specific PKM2 as a target to break this vicious cycle and found that pyridoxine can dimerize PKM2 to restore GSH levels, providing neuroprotection in the MPTP mouse model beyond targeting dopamine receptors
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BD Biosciences, USA) for 30 min, washed with fresh 0.3% BSA, and applied to flow cytometry analysis on an LSRFortessa flow cytometer (BD Biosciences, USA) to count at least 10 000 events
It may accelerate wound closure, reduce scar formation, and support the formation of normal tissue architecture
DOI: 10.1053/j.gastro.2017.06.004
