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Fluid balance effects : Spironolactone helps remove excess fluid, while Mounjaros digestive side effects, like vomiting or diarrhoea, can sometimes lead to dehydration

Boland BB, Brown C, Boland ML et al (2019) Pancreatic -cell rest replenishes insulin secretory capacity and attenuates diabetes in an extreme model of obese type 2 diabetes

One other important note to make here: Only 57.3% of CagriSema patients reached the highest dose by 68 weeks, compared to 82.5% for Cagrilintide and 70.2% for Semaglutide monotherapy

Liberated Hb will initiate Fenton reactions to generate free radicals (Kato et al., 2017)

The key consideration with semaglutide specifically is the gastrointestinal side effect profile