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Warmth increases blood flow, which accelerates the clearing of inflammatory mediators and cellular debris from the hardened area

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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (52), cells (such as dendritic, B cells, and T cells) (52), and gut microbes or toxins (355) to translocate into the brain and promote inflammation ( Figure 10 )