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Evidence Gaps: Most positive findings come from topical formulations or small studies

The depth of skin that is removed is extremely thin

The addition of the AHK-Cu complex may potentially have stimulated the proliferation of normal dermal fibroblasts and possibly enhanced their viability

In a 2003 cell-culture study published in Bulletin of Experimental Biology and Medicine , Khavinson and colleagues reported that Epithalon induced telomerase activity and produced telomere elongation in telomerase-negative human fetal fibroblast cultures, with the authors concluding that the peptide may extend the proliferative lifespan of cell populations through anti-senescence activity [1]

These effects may arise from the peptides capacity to modulate local growth factors and attenuate inflammatory pathways

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