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Regulatory nods for Wegovy in Mexico and Brazil widen eligibility to millions of high-BMI adults, while cardiovascular-outcome data support use in secondary prevention
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Many adults may opt not to take drugs, and even the reduced cost of Wegovy and Zepbound might still be unaffordable for millions
IP3 may potentially trigger the release of calcium ions (Ca2+) from intracellular stores, while DAG potentially activates protein kinase C (PKC)
Indeed, some semaglutide users without IBS already report constipation as a side effect, and in an IBS-C patient whos prone to sluggish bowels, the added delay can lead to harder, less frequent stools
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