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The only notable positive outcome was the reduction of A42 in plasma neuronal EVs, which may reflect the neuronal condition in the systemic circulation
Adv Nutr 14(4):710717
Mittal et al
For most adults, initial dual therapy is recommended: Metformin + SGLT-2 inhibitor Treatment should then be individualized based on comorbidities: Atherosclerotic cardiovascular disease: consider adding GLP-1 receptor agonists such as semaglutide Chronic kidney disease: SGLT-2 inhibitors remain foundational, with DPP-4 inhibitors as additional options when needed
why else file the CSP
Strategic supplementation fills those gaps without adding unnecessary calories
