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This modulatory effect suggests a fundamentally different mechanism and a potentially superior safety profile for cardiovascular applications

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The Cox proportional hazards model was used to calculated adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for outcomes associated with the use of GLP-1 RAs

The GLP-1 analog, liraglutide, did not induce inflammatory genes expression in activated PSCs, but induced proliferation

The action of GLP-1(7-36) on cells may be more indirect, such as through the influence on hormones secreted by and cells (insulin and glucagon), which indirectly affects cell somatostatin secretion

Investigations are underway to determine whether it could be a potential treatment or preventive measure for neurodegenerative diseases like Alzheimer's and Parkinson's disease