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Although nNOS and eNOS are mainly expressed steadily in neurons and endothelial cells regardless of the cell's metabolic state, iNOS exists in trace amounts under healthy conditions and is synthesized de novo in some immunological cells, such as microglia, via inflammatory triggering (32)

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As evidence grows, we can expect to see these treatments adopted more widely in standard clinical practice

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List price is in the $1000-1300 per month range, with actual net price being lower due to rebates and savings/coupons from the manufacturers