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In its active form, the peptide binds divalent copper ions (Cu), with the histidine residue serving as the primary coordination site

Zhao Y, Jia M, Chen W, Liu Z (2022) The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Repeated freeze-thaw cycles should be avoided when possible, as each cycle can cause incremental loss of activity through partial aggregation

Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer

DIA Global Forum, "The Hidden Governance Gap in Modern Clinical Trials," Mar 9, 2026

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