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Regionally, Asia-Pacific dominates both production and consumption, particularly markets like China, Japan, and South Korea, followed by growing demand in North America and Europe

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Apoptotic malfunctions contribute to the development of resistance to hypoxia-induced tumors, which is crucial for the efficacy of anti-cancer treatments that rely on the activation of apoptosis through various members of the caspase protease family [254]

Full details are reported previously (Vivarelli et al., 2016)

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