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Instead the Fab 3F52/ECD structure is compatible with a tilted conformation of the ECD, where Fab 3F52 occupies partially the orthosteric binding site of the GLP-1R TM domain explaining the competitive effect of Fab 3F52 on BMS21-induced activation of GLP-1R (Fig

5 Conclusion CHF combining RG showed better therapeutic effects than RG alone, and its renal protective effects were associated with reducing Scr, BUN, UA, and improving eGFR, as well as preventing renal fibrosis

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However, it should be used under medical supervision

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