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The radioactivity of the plasma, tissue, bile, urinary, and fecal samples was analyzed using a liquid scintillation counter

In Part 1, participants in Cohort A (n=465), without Type 2 diabetes, were assigned to one of four monthly fixed dose arms (placebo, 140 mg, 280 mg, 420 mg) or an 8-week 420 mg dose arm

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No single type of exercise was clearly superior, although mixed exercise programmes and resistance training appeared slightly more effective than aerobic exercise alone