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Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015

Whether you are talking about trauma, an infection, toxins, or allergies, your immune system answers the same chemical cascade

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Indeed, several studies have reported some level of sex-dependent differences in susceptibility to liver damage

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