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In vivo inhibition of NLRP3 either by administration of MCC950 (NLRP3-inhibitor), or genetic deletion of NLRP3, significantly attenuated liver damage, neutrophil infiltration, NETs formation and fibrosis in steatohepatitis model

The only downside is that semaglutide often comes with the side effect of fatigue, which can make it more difficult to want to exercise

The mechanism of action also produces modest weight loss through calorie elimination (approximately 200 to 300 calories daily)

[i] Kahn, A., Pletcher, P., (2023)

2022 The major difference between these agents lies in canagliflozin, which is less selective for SGLT2 over SGLT1 and is metabolized primarily in the liver (compared to kidneys), and sotagliflozin, which inhibits both SGLT1 and SGLT2

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