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Free radicals are unstable atoms that can cause damage to cells, proteins, and DNA if they accumulate in the body
Specifically, iron overload conditions have been shown to increase the expression and activity of T-type calcium channels, leading to enhanced iron influx into the cardiomyocytes
Stomatologiia, 64(1), 2022
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When the production of this substrate is high, the conversion of the oxidized forms of GPxs or Prxs to their reduced forms cannot match the rate of conversion of their reduced forms to oxidized forms
Some GSTs display glutathione peroxidase activity and these GSTs can detoxify toxic lipid hydroperoxides that accumulate during infections
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