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the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science
In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner
The sample of this study was 23 months female Balb/c mice, divided into negative control and ginger honey intervention as much as 28mg/20g BW for 14 daysthe ELISA method used to examine cortisol hormone, glutathione levels, and estrogen levels
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