Pay in 4 interest-free payments of $6.86 Learn more
Ships within 48 hours · Estimated delivery Aug 19 - Aug 24
Reported applications include NNMT enzyme inhibition assays measuring 1-methylnicotinamide formation or S-adenosylhomocysteine release, intracellular target-engagement assays in differentiated 3T3-L1 adipocytes where 5-Amino-1MQ reduced intracellular 1-methylnicotinamide with an EC near 2.3 M (Neelakantan et al., Biochem Pharmacol, 2018), membrane permeability and Caco-2 transport characterisation, methyltransferase selectivity panels covering COMT, DNMT1 and PRMT3, and rodent studies of NNMT inhibition in adipose tissue and liver following the antisense knockdown work of Kraus and colleagues (Nature, 2014)
The samples were analysed by 520% PAGE and western blotting was performed using an anti-Met rabbit mAb (D1C2, Cell Signaling Technology)
Signs of dehydration to watch: dark urine, dizziness when standing, dry mouth, reduced urine output
Frontiers in Pharmacology, 6 , 30
Discuss these considerations with your independent licensed healthcare provider
People with liver or kidney disease, G6PD deficiency, iron overload, or known allergies to any components should skip IV antioxidant therapy
US$ 29.16
US$ 20.15
US$ 26.67
US$ 22.12
