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Mistake 5: Not accounting for dead space Some syringes retain a small amount of medication in the needle hub after injection, typically 0.5 to 1 unit

However, its important to note that these studies were done in vitro (in a test tube/culture), not in humans

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Of note is that tirzepatide was reported to cause biased signaling at GLP-1R in favor of cAMP response over -arrestin recruitment 35

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