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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

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putida led to the induction of several host genes that encoded defense-related proteins such as PR-1, PR-4, catalase, metallothionein, and a GST (Agisha et al., GSTs may significantly increase plant disease resistance

Acetaminophen produces neurotoxic effects on rat brain neurons both in vitro and in vivo , its use during pregnancy is associated with teratogenic defects in testicular function and the gastrointestinal tract, and there is increased incidence of asthma in maternally exposed and postnatally exposed children

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