[3] [4] Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating
The article says GLP-1 medications suppress appetite by activating receptors in the hypothalamus and brainstem, and that once the medication stops those pathways revert to baseline, restoring pre-treatment appetite levels and eating behaviors
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The harsh condition is evident from the data
Stenman LK, Lehtinen MJ, Meland N, et al
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