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One consideration is that both medications can influence appetite and nausea in opposite directionssertraline may stabilize mood-related eating patterns, while semaglutide suppresses hunger signals

Both medications use small subcutaneous injections similar to insulin injections

Because of that, we had to allow people on these medications to enroll in the study because that's ethically what is required

GLP-1 receptors are expressed throughout the brain, particularly in the hypothalamus (arcuate nucleus), area postrema, nucleus tractus solitarius, and dopaminergic reward circuitry

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Prozac, although not primarily a medication for diabetes, may also have some indirect effects on blood sugar levels