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Lyttle MH, Docker MD, Hui HC, Caldwell CG, Aaron DT, Engqvist-Goldstein A, Flatgaard JE and Bauer KE

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Aside from the unknown temporal dynamics of mitochondrial dysfunction, clinical trials in neurodegenerative diseases, in general, face unique challenges with long interventional periods, the need for sophisticated trial designs (delayed-clinical trials or adaptive designs), and a priori patient-stratification

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The body is then minimally capable of regenerating damaged tissue (21)

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