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Oz HS, McClain CJ, Nagasawa HT, et al

Furthermore, although rare, severe toxicities like lactic acidosis are often preceded by a decline in mtDNA copy number together withrising serum lactate, suggesting that serial monitoring in high-risk individuals could allow earlier detection, although current evidence remains limited ( The utility of mtDNA extends to assessing immunological failure and exhaustion

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Geary N, Kissileff HR, Pi-Sunyer FX, Hinton V