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This dual mechanism is significant because, as mentioned earlier, tirzepatide maintained anti-inflammatory effects even when neuronal GLP-1 receptors were knocked out in animal models

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Numerosos estudios clnicos han demostrado que puede reducir los niveles de azcar en sangre de manera comparable a la metformina, un frmaco de referencia en el tratamiento de la diabetes tipo 2

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The direct and indirect anti-inflammatory actions of GLP-1RA may also contribute to resolution of hepatic inflammation in people with metabolic liver disease and non-alcoholic steatohepatitis (NASH) (Figs 3, 4) [148]