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However, their clinical translation is often impeded by inherent challenges such as poor bioavailability, limited aqueous solubility, and rapid systemic clearance, which collectively hinder their effective delivery to targeted ocular tissues [347]
Their mechanisms of action arent always clearly defined
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Considering the phospholipid profile, we observed a profound remodeling in fatty acid composition (i.e., raised content of saturated species, reduced content of polyunsaturated species), which was in turn accompanied by an overall decrease in lyso-phospholipids
They represent what has been studied, not a personalized recommendation
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