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Mechanistically, these meds slow stomach emptying and enhance fullness, which is part of why they workand part of why GI symptoms happen

There are quite a few genetic variants that decrease the production of methyl groups, including MTHFR variants

Seek medical attention if green stools accompany severe abdominal pain, fever, blood in stools, persistent vomiting, or signs of dehydration

The findings are compelling as proof of concept, and they are mechanistically coherent with what the human observational and clinical data suggest